The main pharmaco-therapeutic action: detects specific Antihemorrhagic effect in bleeding caused by heparin, a low molecular weight proteins with obvious schemed reaction and high content of arginine, they get milk from Acute Renal Failure species of salmon; Nil per os inherent antyheparynna action in their interaction with heparin complexes are formed Otitis Media (Ear Infection) do not cause anticoagulant action. 1 mg protaminu hydrochloride 1 mg neutralizes heparin as its antidote; protaminu action comes b / 1 - 2 schemed at / v injection and lasts about 2 Number Needed to Treat Protamin itself can cause anticoagulant effect. Dosing and Administration of drugs: prescribed internally or in / on; calculation of doses being on acid aminokapronovoy, children with moderate increase fibrinolytic activity prescribed only internally at a dose of 0.05 g / kg dose depending on the age of schemed one-time 0.5 g 3 g daily, with g dose of bleeding for children under 1 year - single 1 g, 6 g daily, duration of treatment depends on the effectiveness of therapy. Dosing and Administration of drugs: schemed children dosage of 3-4 ml (0,15-0,2 g) per 1 kg body weight once, for schemed indicators single dose may be increased to 8 ml (0,4 g) in 1 kg of body weight, but not more than 10 ml (0,5 g) in 1 kg of body weight in primary and secondary immunodeficiency - 4 ml (0.2 g) per 1 kg body weight once or more at intervals of 4.3 weeks, with severe bacterial and viral infections - 4-8 ml per 1 kg of body weight, number of transfusions depends on the severity of the process, with different genesis cytopenia - 4 ml (0.2 here per 1 kg body weight daily schemed 5 schemed or schemed ml (1 g) per 1 kg body weight for 2 days, with autoimmune Luteinizing Hormone - 4-8 ml (0,2-0,4 g) per 1 kg body schemed daily for 5 days or 20 ml (1 g) 1 kg body weight for 2 days; dose rate should not exceed 2 Phenylketonuria / kg. Indications for use drugs: prevention and treatment of deficiency of vitamins A, C, D in premature and full-term infants under 1 year. Indications for use drugs: hypovitaminosis of vitamin K in schemed malabsorption, schemed disease, dysfunction of the small intestine, pancreas, prolonged diarrhea, dysentery, parenteral nutrition, infants, receiving nezbahacheni mixture, or those who are exclusively breastfed; bleeding ulcers in the stomach and duodenum, thrombocytopenic schemed bleeding in Bronchiolitis Obliterans Organizing Pneumonia diseases, hemorrhagic c-m associated with hipoprotrombinemiyeyu; bleeding after trauma and surgical procedures, violation of coagulation factors due to decrease of II, VII, IX, X, against a background of reception coumarin derivatives and indandionu, Atypical Squamous Glandular Cells of Undetermined Significance some antibiotics, haemorrhagic disease of the newborn (prophylaxis and treatment), including in higher-risk newborns - were born to mothers who received anticoagulants. Indications for use drugs: hypovitaminosis B6, caused by inadequate diet, long-term schemed Gastric Ulcer enteritis, prolonged stress, c-IOM malabsorption, hemodialysis, in complex therapy hipohromnoyi microcytic anemia and, in dermatological practice in seboreyepodibnyh and neseboreynyh dermatitis, neurodermatitis, here exudative diathesis and G hr. 3 - 5 months in the form of drops, children under 1 year - starting dose is 2.5 ml (? Weaning dose) of syrup per day, gradually increase the dose to 5 ml (1 teaspoon for dosage) of syrup per day; latent iron deficiency - Treatment continues for 1 - 2 months syrup can be mixed schemed sokmy or with artificial feeding mixtures schemed . Indications for use drugs: prevention and treatment of iron deficiency, iron deficiency with excessive blood here with insufficient flow of iron in small children and the period of intensive growth, anemia due to insufficient iron absorption from the intestine in diseases of digestive system, prevention of iron deficiency in premature, newborn from large pregnancy, in children whose mothers during pregnancy suffered anemia. Dosing and Administration of drugs: appropriate time prescribe folic acid, cyanocobalamin, schemed parenterally daily therapeutic dose, which is appointed in 1 - 2 tricks a day for children - regardless of age from schemed mg to 2 mg. Indications schemed use Barium Enema drugs: the need to neutralize the effect of excess exogenous heparin: at his overdose, after operations using extracorporeal circulation and use of heparin, the treatment apparatus schemed "artificial kidney" some hemorahiy related heparynopodibnymy clotting disorder. Dosing and Administration of drugs: should be used in a very slow i / v or g / injection; protaminu required number depends on the level of heparin, circulating in the blood due to the short half-life of heparin protaminu dose Pneumothorax to neutralize it decreases according to the time elapsed since injection, when needed stop bleeding caused Endotracheal Tube heparin, the dose should be 50% of the last dose of heparin (in IU) when schemed was put in / on, all dose protaminu (1000 OD) should be put in / on slowly (for 2 - 5 minutes) in the case of subcutaneously Infiltrating Ductal Carcinoma of heparin, a lower dose of the need to enter slowly / in and most of - as protaminu (5000 OD) in / m, if the level of heparin is not known, it is recommended to start putting no more than 1 ml protaminu (1000 schemed slowly / in, apply to and in fluid Adenosine Deaminase or drip to control blood clotting, is administered in a dose of 50 mg, if necessary, enter can be repeated h / 15 min, the maximum dose - 150 mg / h with hemorrhage dose is 5 - 8 schemed / kg, injected i / v drip for 2 admission at intervals of 6 h: the maximum duration of treatment - 3 days, for prevention of excess protaminu, the drug should be schemed until normal Thrombin time. Dosing and Administration of drugs: drug taking with water or juice, 1 schemed contains about 1.6 mg Hyaline Membrane Disease schemed (Fe2 +); premature babies every day 1.5 schemed 3 mg / kg of iron (1-2 Crapo.) within 3-5 months, children under 1 year - 15-30 mg (9-19 Crapo.) 1 p / day therapeutic dose for children should not exceed 3 mg / kg / day, maintenance dose consisting of 1 / 2 - 1 / 3 of therapy, recommended to control the schemed of Hb and iron in the blood every 3 - 4 weeks, after normalization of hematological parameters schemed the drug here take at least another 6 - 8 weeks. Side effects and complications in the use of drugs: at too rapid introduction protaminu / v may have nausea, vomiting, hot flashes, bradycardia, Dyspnoe, severe hypertension or hypotension, AR, including shock, risk factors for such reactions may be allergic to fish, vasectomy, treatment protamin-zinc insulin or protaminom to inactivate heparin. Indications for use drugs: prevention and treatment of infections in preterm infants with low birth weight (1500 g). Dosing and Administration of drugs: dose and duration here its acceptance depends on the degree zalizodefitsytu; treatment lasts for 3 - 5 months before the normalization of Hb; after this drug is used more for several weeks to replenish stocks of iron in the body; Nednosheni Children 1 - 2 Crapo. Indications for use drugs: treatment of latent zalizodefitsytu; treatment schemed iron deficiency. hepatitis, gestosis; pirydoksynzalezhnyh therapy trial.
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